Mult Scler. 2006 Aug;12(4):487-94.
Fatigue in progressive multiple sclerosis is associated with low levels of dehydroepiandrosterone.Tellez N, Comabella M, Julia E, Rio J, Tintore M, Brieva L, Nos C, Montalban X.
Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain. firstname.lastname@example.org
BACKGROUND AND OBJECTIVE: Fatigue is one of the most limiting symptoms in multiple sclerosis (MS) and the mechanisms underlying its origin are poorly understood. Our aim was to test whether fatigue in MS is associated with endocrine markers. METHODS: We longitudinally studied 73 progressive MS patients. Fatigue was assessed at baseline and at 3, 6, 12 and 24 months using the Fatigue Severity Scale (FSS). Given the longitudinal design of our study, patients were labelled as sustained fatigued when FSS scores were >5.0 at all time points, and as non-fatigued when FSS scores were < or = 5.0 at all time points. Serum levels of dehydroepiandrosterone (DHEA), its sulphated conjugate (DHEAS) and cortisol were measured at each time point. RESULTS: Twenty-nine patients scored >5.0 in the FSS at all time points, and 9 patients (12.3%) scored 5.0 at all time points. Mean baseline levels of DHEAS and DHEA were lower in MS patients with sustained fatigue when compared to patients without fatigue (P = 0.01 and P = 0.03 respectively). Analysis of DHEAS and DHEA over time showed significantly lower hormone levels in patients with fatigue [F(1,31) = 6.14, P=0.019 for DHEAS; F(1,32) = 6.63, P=0.015 for DHEA]. CONCLUSIONS: Fatigue in progressive MS could be related to low serum levels of DHEA and DHEAS. Our results suggest that these hormones should be considered as biological markers of fatigue in MS patients and that hormone replacement may thus be tested as an option to treat fatigue in MS patients.
Monday, August 14, 2006
Research: MS fatigue linked to DHEA levels
God help me, I'm thinking of going down to Walgreen's this afternoon to buy some DHEA and conduct my own N=1 study of DHEA supplementation. For the last couple weeks, my legs (especially the left one) have felt like a couple of oversized rubber chickens attached to my hips.