Wednesday, August 23, 2006

Research: Extensive remyelination?

Autopsies indicate that some 20% of MS patients have been busy remyelinating their lesion areas. I'd just like to say cheers to the specimens who, um, participated in this research. First, kudos to you for remyelinating. I wish I knew how to do that. Second, thanks for your generous foresight in donating your recently-vacated corporeal forms. Here's a snip from the abstract:
The extent of remyelination was variable between cases. In 20% of the patients, the extent of remyelination was extensive with 60-96% of the global lesion area remyelinated. Extensive remyelination was found not only in patients with relapsing multiple sclerosis, but also in a subset of patients with progressive disease. Older age at death and longer disease duration were associated with significantly more remyelinated lesions or lesion areas. No correlation was found between the extent of remyelination and either gender or age at disease onset. These results suggest that the variable and patient-dependent extent of remyelination must be considered in the design of future clinical trials aimed at promoting CNS repair.


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